multiple sclerosis — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TP2315	Glatiramer Acetate		Others
	Glatiramer acetate (GA) is a synthetic amino acid copolymer that is approved for treatment of relapsing remitting multiple sclerosis (RRMS) and clinically isolated syndrome (CIS).		Others
T4903	Heptadecanoic acid		Others , Endogenous Metabolite
	Heptadecanoic acid is a fatty acid of exogenous (primarily ruminant) origin. Many "odd" length long chain amino acids are derived from the consumption of dairy fats (milk and meat). Heptadecanoic acid constitutes 0.61% o...		Others , Endogenous Metabolite
T4283	SRI-011381		TGF-beta/Smad
	SRI-011381, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.		TGF-beta/Smad
T9125	Tolebrutinib	PRN2246,SAR442168	BTK
	Tolebrutinib (PRN2246) is a potent, selective, orally active and brain-penetrant Bruton tyrosine kinase (BTK) inhibitor(IC50s of 0.4 and 0.7 nM in Ramos B cells and in HMC microglia cells, respectively). It exhibits effi...		BTK
T13408	ZK824190		Others , Serine Protease
	ZK824190 is an orally available and selective inhibitor of urokinase plasminogen activator (uPA) as a potential treatment for multiple sclerosis(IC50s of 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively).		Others , Serine Protease
T6403	Siponimod	BAF-312	S1P Receptor , LPL Receptor
	BAF312 (Siponimod (BAF-312)), a next-generation S1P receptor modulator, is specific for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, respectively. The specificity of BAF312 for S1P1 and S1P5 receptors exhibi...		S1P Receptor , LPL Receptor
T6923	Ozanimod	RPC-1063	S1P Receptor , LPL Receptor
	Ozanimod (RPC-1063) (RPC1063) is a specific oral S1P Receptor 1 modulator. Ozanimod has been used in trials studying the treatment of Crohn's Disease, Ulcerative Colitis, Multiple Sclerosis, and Relapsing Multiple Sclero...		S1P Receptor , LPL Receptor
T4031	S1p receptor agonist 1	S1p-receptor-agonist-1	S1P Receptor , LPL Receptor
	S1p receptor agonist 1 (S1p-receptor-agonist-1) is an S1P receptor agonist.		S1P Receptor , LPL Receptor
T6561	Laquinimod	LAQ,ABR-215062	Apoptosis , Others , NF-κB
	Laquinimod (LAQ) is an effective immunomodulator, which is currently under development in phase III trials for the treatment of multiple sclerosis as an oral therapy.		Apoptosis , Others , NF-κB
T5129	SRI-011381 hydrochloride	SRI-011381 hydrochloride [1629138-41-5(free base)]	TGF-beta/Smad
	SRI-011381 hydrochloride, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.		TGF-beta/Smad
T2558	Cladribine	2-chlorodeoxyadenosine,2-Chloro-2′-deoxyadenosine,CldAdo,2CdA	Apoptosis , Adenosine deaminase
	Cladribine (2CdA), an adenosine deaminase inhibitor, is utilized in the treatment of lymphoproliferative diseases.		Apoptosis , Adenosine deaminase
T3044	(E/Z)-Teriflunomide	Aubagio,HMR-1726,Flucyamide,A77 1726	Dehydrogenase
	(E/Z)-Teriflunomide (Aubagio), a orally-available Pyrimidine Synthesis Inhibitor, is used to treat relapsing multiple sclerosis.		Dehydrogenase
T31149	CYM5181	CYM 5181,CYM-5181
	CYM5181 is related to the body's immune system and can be used to study multiple sclerosis, transplant rejection, and adult respiratory distress syndrome.
T67865	BJJF078		Glutaminase
	BJJF078, an aminopiperidine derivative, is a potent inhibitor of recombinant human and mouse glutamine aminotransferase (TG2) activity, with IC50 values of 41 and 54 nM for human and mouse glutamine aminotransferase, res...		Glutaminase
T7534	Teriflunomide	A 77-1726	Others
	Teriflunomide (A 77-1726) is the principal active metabolite of leflunomide, an approved therapy for rheumatoid arthritis and multiple sclerosis.		Others
T77416	Opicinumab	BIIB033	Others
	Opicinumab (BIIB033) is a novel monoclonal antibody against LINGO-1 that may be used to prevent and delay acute optic neuritis and recurrent multiple sclerosis.		Others
T125901	14-Epiandrographolide
	14-Epiandrographolide is a compound derived from the above-ground parts of Andrographis paniculata that induces cell differentiation and can be used in the study of multiple sclerosis.
T12177	Natalizumab		Integrin
	Natalizumab used for the treatment of relapsing remitting multiple sclerosis and Crohn's disease.		Integrin
T73689	Daclizumab	Ro 24-7375,Zenapax	IL Receptor
	Daclizumab (Zenapax) is a humanized monoclonal antibody that specifically inhibits the alpha subunit of IL-2R-HA. Daclizumab (Zenapax) can inhibit the binding of IL-2 and IL-2R-HA through specific binding to CD25. Dacliz...		IL Receptor
T62552	Ozanimod hydrochloride
	Ozanimod (RPC-1063) hydrochloride is a sphingosine 1-phosphate (S1P) receptor modulator that selectively binds S1P receptor subtype 1 (S1P1) and S1P5 (S1P5) with high affinity. Ozanimod hydrochloride can be used to study...